New England Journal Of Medicine Publishes Phase III Results Of VELCADE(R) (Bortezomib) For Injection In Previously Untreated Multiple Myeloma Patients

�Millennium: The Takeda
Oncology Company proclaimed the publication of results from the 682
patient role, randomized, Phase III VISTA(1) trial in this week's edition of the
New England Journal of Medicine. The results showed a significant natural selection
benefit and a 30 percent nail remission (CR) rate with VELCADE,
alkeran and meticorten (VcMP) compared to 4 percent for melaphalan and
prednisone (MP) alone in previously untreated multiple myeloma patients.
Multiple myeloma is the second most common blood cancer.



"These data demonstrate that treatment with VELCADE asset melphalan and
prednisone leads to a survival benefit and a high nail remission in
previously untreated patients with multiple myeloma," said Professor Jesus
San Miguel, M.D., Ph.D., Hematology Department Head, University Hospital of
Salamanca and Principal Investigator of the test. "The combination of
VELCADE plus alkeran and meticorten is an important fresh option for these
patients."



These data originally were presented at the 2007 American Society of
Hematology (ASH) Annual Meeting. Based on these positive tribulation results, the
U.S. Food and Drug Administration approved VELCADE for patients with
previously untreated multiple myeloma on June 20, 2008. The Phase III VISTA
trial was conducted by Millennium and its co-development partner Johnson &
Johnson Pharmaceutical Research & Development, L.L.C. in 151 centers
worldwide.



"We are proud to have these information published in such a highly honored
journal," said Nancy Simonian, M.D., Chief Medical Officer, Millennium.
"We're delighted that previously untreated multiple myeloma patients now
can benefit from this VELCADE based therapy as have patients in the
relapsed and refractory settings since 2003."



(1) VELCADE as Initial Standard Therapy in multiple myeloma: Assessment
with alkeran and prednisone

VISTA Trial Results



Patient responses were evaluated by the stringent European Group for
Blood and Marrow Transplantation (EBMT) criteria:



-- A CR rate of 30 percent in the VcMP arm compared to 4 percent with
MP (p


-- VcMP demonstrated statistical significance in overall survival with
a 39 percent reduction in danger of death (Hazard ratio= 0.61; p=0.008) with
a follow-up of 16.3 months



-- The median treatment continuance was 46 weeks for the VcMP arm compared
to 39 weeks for the control arm and discontinuation ascribable to inauspicious events
was similar in both arms



Patients in the VcMP arm received VELCADE at 1.3 mg/m2 twice weekly in
weeks one, two, four and basketball team for foursome six-week cycles (eight doses per
bike), followed by once weekly on weeks one, 2, four and five for up to
five six-week cycles (four doses per cycle) in combination with melphalan
at 9 mg/m2 and liquid Pred at 60 mg/m2 at one time daily on days 1 through 4 of
each cycle for up to nine six-week cycles. For both groups, treatment
continued for a maximum of 54 weeks.



"The tolerability of VcMP also was encouraging and side effects were
more often than not manageable with appropriate supportive care and dose reduction as
needed," commented Paul Richardson, M.D., Clinical Director of the Jerome
Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute and Senior
Investigator on the study.



The safety profile of VELCADE in combination with MP is consistent with
the known safety profiles of both VELCADE and MP. In VISTA, the most
usually reported untoward events for VELCADE in combination with MP vs MP,
respectively, were thrombocytopenia (52% vs 47%), neutropenia (49% vs 46%),
sickness (48% vs 28%), peripheral neuropathy (47% vs 5%), diarrhea (46% vs
17%), anemia (43% vs 55%), constipation (37% vs 16%), neuralgia (36% vs
1%), leukopenia (33% vs 30%), vomiting (33% vs 16%), pyrexia (29% vs 19%),
fatigue (29% vs 26%), lymphopenia (24% vs 17%), anorexia (23% vs 10%),
asthenia (21% vs 18%), cough (21% vs 13%), insomnia (20% vs 13%), edema
peripheral (20% vs 10%), skin rash (19% vs 7%), endorse pain (17% vs 18%),
pneumonia (16% vs 11%), dizziness (16% vs 11%), dyspnea (15% vs 13%),
headache (14% vs 10%), pain in extremity (14% vs 9%), abdominal painfulness (14%
vs 7%), paraesthesia (13% vs 4%), herpes zoster (13% vs 4%), bronchitis (13%
vs 8%), hypokalemia (13% vs 7%), hypertension (13% vs 7%), abdominal pain
upper (12% vs 9%), hypotension (12% vs 3%), dyspepsia (11% vs 7%),
nasopharyngitis (11% vs 8%), bone pain in the neck (11% vs 10%), arthralgia (11% vs
15%) and pruritus (10% vs 5%).

Important Safety Information



In the U.S., VELCADE is indicated for the treatment of patients with
multiple myeloma. VELCADE besides is indicated for the treatment of patients
with mantle cell lymphoma world Health Organization have received at least one prior therapy.
VELCADE is contraindicated in patients with hypersensitivity to bortezomib,
boron or mannitol. VELCADE should be administered under the supervising of
a physician experienced in the use of antineoplastic therapy.



Risks associated with VELCADE therapy include new or worsening
peripheral neuropathy, hypotension throughout therapy, cardiac and
pulmonary disorders, reversible buns leukoencephalopathy syndrome,
gastrointestinal adverse events, thrombopenia, neutropenia, tumour lysis
syndrome and liverwort events. Women of childbirth potential should avoid
becoming pregnant spell being toughened with VELCADE. Nursing mothers are
advised not to breastfeed while receiving VELCADE. Cases of severe sensory
and motor peripheral neuropathy have been reported. The long-term event
of peripheral neuropathy has not been studied in mantle cell lymphoma.
Acute development or exacerbation of congestive warmheartedness failure, and new
onset of decreased left ventricular ejection fraction has been reported,
including reports in patients with no risk factors for decreased leftfield
ventricular expulsion fraction. There have been reports of acute permeate
infiltrative pulmonary disease of unknown aetiology such as pneumonitis,
interstitial pneumonia, lung infiltration and Acute Respiratory Distress
Syndrome in patients receiving VELCADE. Some of these events have been
fatal. There have been reports of Reversible Posterior Leukoencephalopathy
Syndrome (RPLS) in patients receiving VELCADE. RPLS is a rare, reversible,
neurological disorder which can buoy present with seizure, high blood pressure,
headache, inanition, confusion, cecity, and other visual and neurological
disturbances. VELCADE is associated with thrombocytopenia and neutropenia.
There have been reports of gastrointestinal and intracerebral bleeding in
association with VELCADE. Transfusions may be considered. Complete pedigree
counts (CBC) should be frequently monitored during discourse with VELCADE.
Cases of acute liver failure have been reported in patients receiving
multiple concomitant medications and with serious underlying medical
weather. Patients world Health Organization are concomitantly receiving VELCADE and drugs that
ar inhibitors or inducers of cytochrome P450 3A4 should be closely
monitored for either toxicities or decreased efficacy. Patients on oral
antidiabetic medication while receiving VELCADE should check blood sugar
levels frequently.

Adverse Reaction Data



Safety data from Phase II and III studies of single-agent VELCADE 1.3
mg/m2/dose twice weekly for 2 weeks followed by a 10-day rest period in
1163 patients with previously treated multiple myeloma (N=1008, non
including the Phase III, VELCADE asset DOXIL(R) [doxorubicin HCl liposome
injection] study) and antecedently treated pallium cell lymphoma (N=155) were
integrated and tabulated. In these studies, the condom profile of VELCADE
was similar in patients with multiple myeloma and blanket cell lymphoma.



In the integrated depth psychology, the most commonly reported adverse events
were asthenic conditions (including fatigue, unease and weakness) (64%),
sickness (55%), looseness (52%), irregularity (41%), peripheral neuropathy NEC
(including peripheral sensory neuropathy and peripheral neuropathy
aggravated) (39%), thrombocytopenia and appetite decreased (including
anorexia) (each 36%), fever (34%), vomiting (33%), anemia (29%), hydrops
(23%), head ache, paresthesia and dysesthesia and headache (each 22%),
dyspnea (21%), coughing and insomnia (each 20%), rash (18%), arthralgia (17%),
neutropenia and dizziness (excluding vertigo) (each 17%), hurting in limb and
abdominal muscle pain (each 15%), os pain (14%), back pain in the neck and hypotension (each
13%), herpes zoster, nasopharyngitis, pep pill respiratory tract infection,
myalgia and pneumonia (each 12%), muscle cramps (11%), and dehydration and
anxiety (each 10%). Twenty percent (20%) of patients experienced at least 1
episode of greater than or equalize to Grade 4 toxicity, most unremarkably
thrombocytopenia (5%) and neutropenia (3%). A total of 50% of patients
experient serious untoward events (SAEs) during the studies. The most
ordinarily reported SAEs included pneumonia (7%), febrility (6%), looseness of the bowels
(5%), puking (4%), and nausea, dehydration, dyspnea and thrombocytopenia
(each 3%).

About Multiple Myeloma



Multiple myeloma is the endorsement most mutual hematological malignance.
Between 2001 - 2005, the medial age of diagnosis was 70 long time. In 2007,
there were 110,000 patients living with multiple myeloma across the United
States, Europe and Japan. It is estimated that this number will growth by
5.6 % annually over the next few years due to new therapies extending the
lives of multiple myeloma patients.

About VELCADE



VELCADE is being co-developed by Millennium: The Takeda Oncology
Company and Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Millennium is responsible for commercialization of VELCADE in the U.S. and
Janssen-Cilag is responsible for commercialization in Europe and the perch
of the world. Janssen Pharmaceutical K.K. is responsible for
commercialisation in Japan.

About Millennium



Millennium: The Takeda Oncology Company, and a leading
biopharmaceutical company based in Cambridge, Mass., markets VELCADE, a
novel cancer product, and has a robust clinical development pipeline of
product candidates. Millennium research, development and commercialisation
activities ar focused in oncology. Additional information about Millennium
is available through its site, http://www.millennium.com.


Millennium
http://www.millennium.com



View drug information on Doxil; Velcade.



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Stefani and Rossdale have baby boy

Gwen Stefani and her husband Gavin Rossdale are celebrating the birth of their minute child together.

Their son, Zuma, was born weighing 8.5lbs.

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Download Grandmaster Flash mp3

Artist: Grandmaster Flash: mp3 download    Genre(s):  Electronic     Discography:      The Official Adventures Of    Year: 2002    Tracks: 13      Ministry of Sound Session    Year: 2002    Tracks: 1      Live in NYC    Year: 1995    Tracks: 1      Ba-Dop-Boom-Bang ... and Even More    Year: 1987    Tracks: 18      The Geatest Hits of Grandmaster Flash    Year: 1984    Tracks: 14      More Hits From...    Year: 1984    Tracks: 11      Message    Year: 1982    Tracks: 8      Grandmaster Flash V The Sugarhill Gang    Year:     Tracks: 17 DJ Grandmaster Flash and his group the Furious Five were hip-hop's sterling innovators, transcending the genre's party-music origins to explore the total background of its lyrical and sonic horizons. Flash was natural Joseph Saddler in Barbados on January 1, 1958; he began spinning records as teenager growing up in the Bronx, performing springy at arena dances and impede parties. By old years 19, spell attending skilful school courses in electronics during the day, he was as well spinning on the local discotheque circuit; over time, he developed a series of groundbreaking techniques including "cut" (moving betwixt tracks on the nose on the beat), "back-spinning" (manually turning records to recur brief snippets of sound), and "phasing" (manipulating turntable speeds) -- in short, creating the canonic vocabulary which DJs keep to come with regular today. Flash did non begin collaborating with rappers until around 1977, number one teaming with the fabled Kurtis Blow. He then began working with the Furious Five -- rappers Melle Mel (Melvin Glover), Cowboy (Keith Wiggins), Kid Creole (Nathaniel Glover), Mr. Ness aka Scorpio (Eddie Morris), and Rahiem (Guy wire Williams); the group cursorily became legendary throughout New York City, attracting notice not only for Flash's one and only skills as a DJ merely as well for the Five's masterly rapping, most famous for their signature trading and blending of lyrics. Despite their local popularity, they did non phonograph recording until after the Sugarhill Gang's crush "Rapper's Delight" proved the beingness of a market for rap music releases; after releasing "We Rap More Mellow" as the Younger Generation, Flash and the Five recorded "Superappin'" for the Enjoy label owned by R&B legend Bobby Robinson. They then switched to Sugar Hill, owned by Sylvia Robinson (no relative), after she promised them an chance to rap over a stream DJ front-runner, "Get Up and Dance" by Freedom (the musical theme had belike been originally conceived by Crash Crew for their unmarried "High Powered Rap"). That record, 1980's "Freedom," the group's Sugar Hill debut, reached the Top 20 on national R&B charts on its direction to merchandising over 50,000 copies; its followup, "Natal day Party," was besides a stumble. 1981's "The Adventures of Grandmaster Flash on the Wheels of Steel" was the group's beginning unfeignedly watershed recording, introducing Flash's "clipping" techniques to create a stunning sound collage from snippets of songs by Chic, Blondie, and Queen. Flash and the Five's future effort, 1982's "The Message," was even more revelatory -- for the first time, rap music became a vehicle not just for crowing and self-praise but for searching social comment, with Melle Mel delivering a blistering rap detailing the forbidding realities of life in the ghetto. The record was a major vital hit, and it was an tremendous step in hardening rap as an important and enduring mannikin of musical expression. Following 1983's anti-cocaine polemic "White River Lines," dealings between Flash and Melle Mel sour ugly, and the rapper presently left hand the group, forming a new unit too dubbed the Furious Five. After a series of Grandmaster Flash solo albums including 1985's They Said It Couldn't Be Done, 1986's The Source, and 1987's Da Bop Boom Bang, he reformed the original Furious Five lineup for a jacob's ladder concert at Madison Square Garden; before long subsequently, the reconstituted grouping recorded a new LP, 1988's On the Strength, which earned a lukewarm reception from fans and critics alike. Another reunification followed in 1994, when Flash and the Five joined a blame parcel tour also including Kurtis Blow and Run-D.M.C. A year subsequently, Flash and Melle Mel as well appeared on Duran Duran's cover of "White Lines." Except for a few compilations during the belated '90s, Flash was comparatively quiet until 2002, when a geminate of mix albums appeared: The Official Adventures of Grandmaster Flash on Strut and Essential Mix: Classic Edition on ffrr.

Jerry Lewis says gun in baggage was telethon gift

American Idol star promises "twists and turns"

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Spanish Kid

   
Artist: Spanish Kid

   Genre(s): 
Other
   

---

Discography:


   
 Pieces Of A Man

   Year: 2004   
Tracks: 15

---

 

Seether lines up a busy summer

South African rock band Seether [ tickets ] has lined up a tour of secondary markets, and is bringing along the likes of Sick Puppies [ tickets ] and Finger Eleven [ tickets ] on multiple dates. The tour kicks off on Independence Day at Milwaukee's Summerfest and continues through an Aug. 24 finale in Nampa, ID. Seether is currently enjoying one of its biggest hits to date, "Fake It," which is the lead track off of last October's "Finding Beauty in Negative Places." The second single, "Rise About This," is gaining momentum on the Billboard Hot 100 singles chart, where it sits at No. 92. The album, which follows 2005's gold-certified "Karma and Effect," reached No. 9 on The Billboard 200. The band also released a live, acoustic set, "One Cold Night," in 2006. Sick Puppies are touring in support of the single "What Are You Looking For," taken from the album "Dressed Up As Live," the Australian band's North American debut album.Recently, Sick Puppies--Shimon Moore (guitar and vocals), Emma Anzai (bass), Mark Goodwin (drums)--completed a two-month headline tour, as well as a series of gigs supporting Evanescence, Deftones, Velvet Revolver, Chris Cornell, Flyleaf, Chevelle, Breaking Benjamin, 3 Doors Down and Finger Eleven. Finger Eleven, who scored a hit with the song "Paralyzer," has canceled all June European dates after singer Scott Anderson injured his neck. In a message to fans on Finger Eleven's webpage, he wrote: "You see: I broke something in and around my neck area. Well, the doc says I sprained it. You know how they always say a sprain is worse than a break? Well, I think I'll stick with a sprained neck over a broken one! Am I right, Internet?" The US dates are a go. Finger Eleven is pushing its album "Them vs. You vs. Me."

R. Kelly trial: Sun-Times critic ordered to come to court

There will be no jail time for Jim DeRogatis, but the R. Kelly trial judge ordered the Sun-Times music critic to come to court Wednesday.

A subpoena had been issued compelling him to appear Tuesday, but DeRogatis never showed.

The newspaper argued the renowned music critic never received the subpoena, though a Sun-Times reporter, attorney and the editor-in-chief's assistant all received legal documents indicating he was expected in court, according to statements made before Cook County Judge Vincent Gaughan.




Gaughan said it was possible DeRogatis was unaware of the ordered appearance and would not issue a warrant for his arrest.

"I'm going to give him the benefit of the doubt," Gaughan said.

Gaughan ordered DeRogatis to appear Wednesday so the defense can question him in front of the jury about his connection to the sex tape at the heart of the case. DeRogatis, who first wrote about Kelly's relationships with young girls in 2000, received the video from an unknown sender in early 2002.

The critic turned the tape over to the Chicago police, prompting an investigation that eventually led to child pornography charges against the singer.

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"He's a material witness," Gaughan said. "He turned over [the sex tape], which is the basis of this prosecution."

The Sun-Times intends to appeal the judge's decision and ask the appellate court to bar DeRogatis from being called as a witness until the matter is settled. Gaughan said he will not delay the testimony unless a higher court orders him to do so.

"I have 15 people in the jury box and this trial is into its fourth week," Gaughan said.

Stacy St. Clair

June 3, 2008 2:04 PM: Newspaper's attorney files appeal on critic's behalf--with the wrong court

Arguments continue over whether Sun-Times music critic Jim DeRogatis will have to appear today before the trial judge in the R. Kelly child pornography case.

Sun-Times lawyer Damon Dunn reasserted that it would be a "serious breach" of DeRogatis' rights if he were compelled to testify as a reporter and said he had appealed last week's decision by the judge ordering the critic to testify.

Kelly's defense team wants DeRogatis to testify about the sex tape at the center of the prosecution's case. Specifically, defense attorneys are interested in what DeRogatis may have done with the tape between the time he received it in early 2002 and when he gave it to police.

Dunn asserted that the Illinois reporter's privilege statute protects the critic from having to testify while an appeal is pending. The judge pointed out, however, that Dunn's notice of appeal was filed to the wrong court—at the Daley Center—and as such is not really on file at this point.

"You filed it in the wrong court," Gaughan snapped. "A notice of appeal has to be filed at the appellate court." Gaughan also rehashed his finding that DeRogatis is not protected under the law as a reporter because he is a "a material witness to a crime" and is not protecting a source.

In his opinion issued Monday, Gaughan said the defense could not ask about the source of the tape and that Kelly attorney Marc Martin said the defense had no plans to ask about the source.

"You're protecting something that nobody is after," Gaughan said to Dunn.

Squeeze

   
Artist: Squeeze

   Genre(s): 
Rock
   Pop
   Indie
   

---

Discography:


   
 Essential Squeeze

   Year: 2007   
Tracks: 20


   
 Big Squeeze - The Very Best Of Squeeze - Disk 2

   Year: 2002   
Tracks: 19


   
 Sweets from a Stranger

   Year: 1998   
Tracks: 12


   
 Singles 45's and Under

   Year: 1995   
Tracks: 12


   
 East Side Story

   Year: 1995   
Tracks: 14


   
 Frank

   Year: 1989   
Tracks: 12


   
 Argybargy

   Year:    
Tracks: 11

---

As one of the nearly traditional pop bands of the new wafture, Squeeze provided one of the golf links between classic British guitar pop and post-punk. Inspired heavily by the Beatles and the Kinks, Squeeze was the vehicle for the songwriting of Chris Difford and Glenn Tilbrook, wHO were hailed as the heirs to Lennon and McCartney's throne during their heyday in the early '80s. Unlike Lennon and McCartney, the partnership 'tween Difford and Tilbrook was a true collaboration, with the former writing the lyrics and the latter providing the music. Squeeze never came close to co-ordinated the popularity of the Beatles, only the reason for that is part of their appealingness. Difford and Tilbrook were wry, insidious songwriters that subscribed to traditional pop songwriting values, merely subverted them with literate lyrics and cagey musical references. While their native Britain warmed to Squeeze immediately, sending singles like "Take Me I'm Yours" and "Up the Junction" into the Top Ten, the striation had a difficult time gaining a footing in the states; they didn't suffer a U.S. Top 40 strike until 1987, closely a 10 later their debut album. Even if the radical never had a score in the U.S., Squeeze reinforced a consecrated following that stayed with them into the recent '90s, and many of their songs -- "Another Nail In My Heart," "Pulling Mussels (From the Shell)," "Tempted," "Disgraceful Coffee In Bed" -- became pop classics of the new waving era, as the atomic number 78 status of their compiling Singles 45's and Under indicates.


Chris Difford (b. April 11, 1954; guitar, vocals) and Glenn Tilbrook (b. August 31, 1957; vocals, guitar) formed Squeeze in 1974. Tilbrook answered an advertisement Difford had placed in a store window, and the geminate began writing songs. By the spring of 1974, the duet had recruited pianist Jools Holland (b. Julian Holland, January 24, 1958) and drummer Paul Gunn, and had named themselves Squeeze, after the disowned Velvet Underground album that featured none of the group's original members. Squeeze began playing the palmy gin mill john Rock circuit, although their songs were quirkier and more pop-oriented than many of their peers. By 1976, the striation had added bassist Harry Kakoulli and replaced Gunn with Gilson Lavis (b. June 27, 1951), a quondam tour of duty manager and drummer for Chuck Berry. They had likewise sign-language a contract with Miles Copeland's burgeoning BTM record label and management company. Squeeze had already recorded several tracks for RCA, including two cuts with Muff Winwood, that the label jilted. BTM went insolvent ahead it could release the band's debut individual, "Take Me I'm Yours" in early 1977, just Squeeze was capable to work with John Cale on their debut EP, due to a abbreviate Copeland had arranged with Cale.


Squeeze released their debut EP, Packet of Three, on Deptford Fun City Records, in the summer of 1977 and before long arranged an international get with A&M Records, becoming the label's low new waving act since their calamitous signing of the Sex Pistols. The striation entered the studio with producer Cale later that year to act upon on their debut album, provisionally titled Gay Guys by the group's producer. Cale had the group contrive extinct most of their standard material, forcing them to write newfangled material; consequently, the record wasn't necessarily a good representation of the band's early healthy. By the time the album was released in the spring of 1978, the group and A&M had deserted the record's working title, and it was released as Squeeze. In America, the set and album had to change their identify to UK Squeeze, in order to forefend muddiness with an American set called Tight Squeeze; by the end of the class, they had reverted back to Squeeze in the U.S.. Preceded by the hit single "Take aim Me I'm Yours," the album became a soften success, just the group's on-key British breakthrough arrived in 1979, when they released their second album, Cool for Cats. More representative of the band's good than their debut, Cool for Cats generated two numeral deuce singles in the title track and "Up the Junction." Later in 1978, the EP 6 Squeeze Songs Crammed Into One Ten-Inch Record EP was released. Squeeze well-tried for a seasonal worker reach that year with "Christmastime Day," just the single failed to chart. Kakoulli was fired from the band after the firing of Cool for Cats and was replaced by John Bentley.


Released in the outflow of 1980, Argybargy received the strongest reviews of any Squeeze album to date, and produced mince U.K. hits with "Another Nail In My Heart" and "Pull Mussels (From the Shell)." Both songs, asset "If I Didn't Love You," became hits on college radiocommunication and new wave clubs in America, increasing the band's profile well; it was the first-class honours degree Squeeze album to chart in America, stretch numeral 71. Jools Holland, whose fascination with boogie piano was starting time to sit uncomfortably with Difford and Tilbrook's more and more sophisticated compositions, left the lot in late 1980 to kind the Millionaires; he was replaced by Paul Carrack, at one time of the gin mill rock lot Ace. Following Argybargy, critics in both the U.K. and U.S. were vocation Difford and Tillbrook "the new Lennon and McCartney," and in order to consolidate their growing reputation, Squeeze made an attack at their own Sgt. Pepper with 1981's East Side Story. Initially, the album was to be produced by Dave Edmunds, just the group scrapped those sessions to mold with Elvis Costello and Roger Bechirian. Upon its summer press release, East Side Story was hailed with excellent reviews, only it didn't become a brobdingnagian stumble as expected. Nevertheless, it establish an audience, peaking at numeral 19 in the U.K. and number 44 on the U.S. charts. The soulful, Carrack-sung "Tempted" failed to reach the U.K. Top 40, just it did become the group's first base charting U.S. individual, arrival the Top 50. The country-tinged "Tagged With Love" became the group's third, and last, British Top Ten hit that descend. Carrack left at the end of 1981 to join Carlene Carter's funding band; he was replaced with Don Snow, a classically trained pianist wHO once played with the Sinceros.


Ever since the press release of their debut, Squeeze had been touring and recording without break, and signs of fatigue were patent on Sweets From a Stranger. Though it was the group's highest-charting U.S. album, arrival figure 32 shortly afterwards its springtime button, Sweets From a Stranger was scratchy. In the U,K,, it was a considerable disappointment, reaching issue 37, with its individual "Sinister Coffee in Bed" stall at phone number 51. Nevertheless, the band had earned a considerable fan base, and were able to play Madison Square Garden that summer. Tired of touring and its thwarting commercial fortunes, Difford and Tilbrook distinct to disband Squeeze late in 1982, cathartic the digest Singles -- 45's and Under, shortly after its proclamation. Ironically, Singles peaked at figure threesome on the British charts; it would afterwards go platinum in the U.S..


Though they had disbanded Squeeze, Difford and Tilbrook had no design of end their coaction -- they only wanted to go after other projects. In particular, they saw themselves as songwriters in the classical tradition of Tin Pan Alley or the Brill Building, and began writing for Helen Shapiro, Paul Young, Billy Bremner and Jools Holland. They as well worked on Labelled With Love, a musical based on their songs, which played briefly in Deptford, England early in 1983. The duo released an eponymous record album in the summer of 1984, showcasing a sophisticated new reasoned, as well as long, flow haircuts and coats. The record was a moderate success, only the couple already were cerebration of re-forming Squeeze. Early in 1985, the band reunited to play a charity gig, which prompted Difford, Tilbrook, Holland, and Lavis (world Health Organization had been driving a cab) to permanently reform, adding bassist Keith Wilkinson. Cosi Fan Tutti Frutti was released in the fall of 1985 to positive reviews and fairly successful sales. During 1986, Andy Metcalfe, a member of Robyn Hitchcock & the Egyptians, linked the dance band as a second keyboardist. Babylon and On followed in the fall of 1987, and the album became a surprise run into, stretch bit 14 in the U.K. and generating their biggest American hits -- "Hourglass," which reached phone number 15 on the speciality of MTV's heavy rotation of the song's inventive video, and the Top 40 "853-5937." After completing an external circuit, which featured another concert at Madison Square Garden and a headlining spotlight at the Reading Festival, Metcalfe left the dance band; he was non replaced.


Babylon and On crataegus oxycantha throw been a hit, only Squeeze's renewed success wasn't lasting. The group's following album, Frank, was released in the fall of 1989 and it wasn't given very much a promotional press by A&M. Consequently, it flopped in both the U.S. and the U.K.. During the load-bearing go for Frank, A&M dropped Squeeze, going away the dance band in the cold. Following the tour, Holland left the dance band to concentrate on his calling as a recording creative person, as intimately as a boob tube host for the BBC. Squeeze released a live album, A Round and a Bout, on I.R.S. in the spring of 1990. Early in 1991, the band gestural with Reprise Records and began recording a new record album, hiring Steve Nieve, Bruce Hornsby and Matt Irving as session keyboardists. The resulting album, Play, was released in the fall of 1991 to small attention, part because it received no support from the label. During the Play go, the band hired Don Snow and Carol Isaacs as keyboardists. Over the course of 1992, Difford & Tilbrook began to play the occasional acoustic concert, as Squeeze revamped its touring batting order over again, hiring Steve Nieve as their touring keyboardist. Longtime drummer Gilson Lavis left wing the band afterward that yr to play in Jools Holland's big band; he was replaced by Pete Thomas wHO, care Nieve, was a member of the Attractions.


Squeeze resigned from A&M Records in early 1993 and recorded their new record album, Some Fantastic Place, with Thomas on drums and Paul Carrack on keyboards. Released in the September of 1993, the record album became a chair British rack up, debuting at telephone number 26; it was ignored in the U.S.. During 1994, Thomas left wing the band to join the reunited Attractions; by the end of the year, the grouping had replaced him with Andy Newmark. Prior to the transcription of 1995's Ridiculous, Kevin Wilkinson -- no relation to bassist Keith Wilkinson -- became the group's drummer. Released in the U.K. in the fall of 1995, Ridiculous became a mince hit, generating the hits "This Summer" and "Electric Trains." The record album was released in America in the give of 1996 on I.R.S. Records. Under the identify John Savannah, Don Snow contributed keyboards on Nonsensical and the album's supporting circuit.


During 1996, Squeeze released deuce compilations, the single-disc Piccadilly Collection in the U.S. and the double-disc Surfeit Moderation in the U.K.. The following year, A&M U.K. issued the box set Six of One..., which contained remastered versions of their number one six albums, plus deuce fillip tracks on each platter. A second box, covering the second six-spot albums, was scheduled for release in 1998, just it was canceled after the label folded. By that time, Squeeze had finished their contractual indebtedness for new studio apartment albums with the pronounce. They signed with main Quixotic Records, releasing a unexampled album, Antoine Domino, in November of 1998. Domino was recorded with a new lineup, featuring Difford and Tilbrook, plus Jools Holland's brother Chris Holland on keyboards, bassist Hilaire Penda and drummer Ashley Soan, a former fellow member of Del Amitri.

CD: The Pigeon Detectives, Emergency

If nothing else, you can't fault the Pigeon Detectives' willingness to graft. The Leeds quintet's second album arrives less than a year after their debut. A cynic would say that's probably just as well. The indie bubble that bore them to fame has got to burst soon, and the Pigeon Detectives' place within the pantheon of platinum sellers looks shakier than most. Their early champions were the Kaiser Chiefs, but it's tempting to wonder if their support didn't have an ulterior motive. Perhaps it was aimed at those who cruelly dismissed I Predict a Riot as craven, conservative "ITV indie": you think ITV indie's bad, mate, here's Granada Men and Motors indie.

It's a perception compounded by an interview frontman Matt Bowman gave last year, in which he recounted inviting a fan with "really big tits" onstage. "The crowd were loving it, so I poured a bottle of water all over her white T-shirt. You could see her nipples and everything." The band later claimed this was "absolute bollocks" and badly misrepresented their live shows - which, to hear them tell it, are essentially seminars on feminist empowerment.

Nevertheless, it would be wrong to say the Pigeon Detectives are without qualities. As Emergency proves, what they do is entirely generic, but it's hard to argue with its melodic efficacy. They know how to structure a song: the choruses of Don't You Wanna Find Out and I'm a Liar click perfectly. Sadly, any arising pleasure is entirely blotted out by the unlistenable ugliness of the lyric.

They have three kinds of song. In the first, chief writer Oli Main feels obliged to take someone down a peg or two, which he does using his reliably devastating "oh-so" technique: "You think you're oh-so clever", or "oh-so petty and so pretentious".

The second is the spiteful break-up song, in which the Pigeon Detectives pour scorn on a recently-chucked female with a boorish sneer that beguilingly combines immense self-regard with mind-boggling witlessness: it's like being dumped by Chris Moyles. "I could love you for a day but then I'd hate you for a week," opens Love You For a Day. "If there was something you could say I'd tell you what to speak." The latter line is delivered with a note of triumph, as indeed it might be: after all, what can you speak to a put-down like that?

The third and most remarkable is the song in which Bowman offers a fortunate lady the chance to sleep with him. Lest she get the wrong idea about the degree of commitment involved (perhaps she's seen him onstage, tirelessly advocating women's rights with the aid of some Evian and a mammiferous female, and come to the conclusion that such a sensitive and thoughtful gentleman will make the perfect Life Partner), he emphasises that his favours will be dispensed on a strictly one-off, no-strings basis: "When the sun comes up, there will be nothing wrong, because I will be away from you." You can't accuse him of luring them under false pretences, but nevertheless, his patter may need a tweak. "Although I don't know your name, I will love you just the same for tonight." he advises elsewhere. "Like a flash in your pan, I will take what I can." You quail at criticising one so silver-tongued, but it does seem inadvisable to try and to win a potential conquest by comparing your boudoir technique to a flash in the pan, which according to my dictionary means "promising start followed by failure".

Elsewhere, there isn't much musical progression on offer, unless you count Nothing to Do With You, which features a mandolin sound similar to that on the Smiths' Please Please Please Let Me Get What I Want. You can see why they've done this - placing the band in illustrious northern lineage and so on - but reminding the listener of vintage Morrissey and Marr midway through Emergency seems needlessly cruel, like reading out the menu from Alain Ducasse's Plaza Athénée restaurant to someone eating a Ginster's Scotch Egg Bar.

As Emergency draws to its sophisticated conclusion - the last thing you hear are the words "bell-end" - you're left pondering a deeply unlikely scenario. Unshakably convinced of its irresistible charm and quick-witted genius while giving every outward impression of being both obnoxious and as thick as two short planks, Emergency is the album the Arctic Monkeys might have made if they fired Alex Turner and replaced him with Michael off The Apprentice. What a horrible thought. What a horrible album.


See Also

• Eyes on Venice as Cannes winds down
• Travelling solo from days of old backyard
• Keeping the film Rolling
• Survivor winner struggles with normal life (spoilers)

X Factor fans furious over voting lines

X Factor fans furious over voting lines

A number of 'X Factor' fans ar reportedly derangement that they could non register their votes for losing finalist Rhydian Roberts stopping point Sat night.
According to the BBC, several tV audience are now claiming that they tried to vote up to 10 times on the night simply could not catch through on the Welshman's phoneline.
Rhydian Roberts was beaten by Scottish isaac Bashevis Singer Leon Jesse Jackson in the final of the bear witness on Sat night.
To begin with in the night host Dermot O'Leary had announced that there was only 1% separating the circus tent iI acts of the Apostles.
The BBC site reports that a fan of the show, Gwyneth Greenslade, said that she phoned 10 multiplication to vote for Richard John Roberts simply could not pay off through.
She said that iI of her friends as well tried to vote for the Cambrian opera vocalizer 7 times and 10 times respectively and also failed to register any votes.
Mrs. Greenslade said: "If you tintinnabulation 10 multiplication you gestate to generate through - I was very cross."
"A circle of other people in this area said they couldn't get through. It seems to be rattling unfair."
The reports as well details other complaints from fans world Health Organization failed to register their votes because of occupy networks.
A number of wireless stations of the Cross in Cambria sustain now banned victor Leon Jackson's birdcall from beingness played because of listeners' complaints over ballot on the night of the final examination.
A spokesperson for 'The X Factor' said there were no reports of problems with the speech sound lines for the final exam.
Check come out of the closet our 'X Factor' final photo gallery here.




Extreme Noise Terror

Original Jane's Addiction lineup to perform at US NME Awards

Original Jane's Addiction lineup to perform at US NME Awards

For the first time in almost two decades, the four original members of Jane's Addiction [ tickets ] will hit the stage together during this month's inaugural US NME Awards ceremony.Prompting the reunion was British music mag NME's announcement that it would present the band with the Godlike Geniuses award during the April 23 event, which is set to take place at Los Angeles' El Rey Theatre."When we were in the planning stages of bringing the NME Awards to America, Jane's Addiction were always in our thoughts," NME Editor Conor McNicholas said in a press release. "They are exactly the sort of once-in-a-lifetime, inspirational, aspirational, no-holds-barred, genre-busting, risk-taking, pioneering group which sums up what the NME Awards is all about."The group's imminent performance will mark the first time since 1991 that original bassist Eric Avery has played with frontman Perry Farrell, guitarist Dave Navarro and drummer Stephen Perkins; the latter trio has participated in several reunions sans Avery."OK, so ... short story is that I've decided to do a few songs with Jane's Addiction at the NME awards show," Avery said in a blog entry posted Tuesday (4/15). "... I was really conflicted and I am still unsure that this is the right answer (if there is such a thing) but I am happy to be a part of honoring Jane's. ... I must admit that it has felt really good so far in both heart and mind; just sounds like a cool night. Amazing.""Eric's bass lines and writing contributions are such an integral part of the Jane's sound that the night would feel somewhat incomplete without his presence," Navarro wrote in a Tuesday (4/15) message at his own website. "We couldn't be happier about his decision to join us."Navarro went on to describe an impromptu performance he gave with Farrell at Monday night's (4/14) Axis of Justice show at the Troubadour in West Hollywood, CA."Around 8:00pm I got a text from Perry that read, 'Dave ... Get down here. [Red Hot Chili Peppers bassist] Flea is on his way and wants to jam!' Of course I accepted the invitation and immediately rolled over to joined Perry, Flea and Travis Barker (Blink-182, Plus 44) for an impromptu Mountain Song."... it gave Perry and I an opportunity to perform again in front of a public audience before hitting the awards show next Wednesday," Navarro continued. "I have had the good fortune throughout my years as a guitarist to share the stage with some unbelievable talents, but there is no one in the world that I feel more comfortable and at home with musically than Perry Farrell."

Kidman confirms pregnancy reports

Kidman confirms pregnancy reports

Oscar-winning actress Nicole Kidman has confirmed that she is expecting a baby with her singer husband Keith Urban.
The 40-year-old Australian star has pulled out of filming for her next movie 'The Reader'.
Kidman's publicist, Wendy Day, confirmed the news in a statement, saying: "Nicole Kidman and Keith Urban confirmed today that they are expecting a baby. The couple are thrilled."
Referring to Kidman's decision to pull out of her next movie, her publicist said: "I understand she's had to withdraw from the film and therefore she's had to give them the reason, and therefore she's now able to confirm that she's pregnant."
"I don't know how far pregnant she is, or when the baby's due. She just simply rang me and said, 'Wendy I always told you I would tell you first, and I'd confirm it and you could make the appropriate announcement'."
Kidman and Urban married in 2006. The actress already has two adopted children from her marriage to actor Tom Cruise, 15-year-old Isabella and 12-year-old Conor.

Mario Schonwalder and Detlef Keller, Bas Broekhuis

   
Artist: Mario Schonwalder and Detlef Keller, Bas Broekhuis

   Genre(s): 
Electronic
   

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Discography:


   
 Wolfsburg

   Year: 2002   
Tracks: 3

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Sabbat

New Zealand Symphony Orchestra at the Auckland Town Hall

New Zealand Symphony Orchestra at the Auckland Town Hall

English cellist Natalie Clein and Finnish music director Pietari Inkinen proved a galvanic partnership in the first two concerts of the Newly Seeland Symphony orchestra Orchestra's 2008 time of year.

Clein's 1777 Guadagnini violoncello was in full and glorious voice from the start. Her reception to Elgar's numerousness of markings and directions was scrupulous to the last quiver of bow on strand.

The blithe sinlessness of the number 1 movement turned confrontational in the second and Inkinen made the orchestral weight of the account felt. The Adagio, suffused with autumnal lyricism, most seemed to sob, spell the Finale was painted in more ominous colors.

An encore of a Bach Preliminary was quirkily, well-nigh skittishly delivered, and a draw to a lesser extent effective and convincing when presented over again on the Sabbatum night.

Just Clein's offer on her second appearance, Tchaikovsky's Variations on a Rococo Theme, was tout ensemble less meaty. After a series of orchestral bows and curtsies, the violoncello leads us firmly into the beauty salon and, although Clein entranced with so many details, Tchaikovsky's score did non coalesce as had Elgar's on the previous evening.

Few concert-goers would have been expecting Pietari Inkinen to




McCoy Tyner

Did poison kill James Brown?

Did poison kill James Brown?

James BROWN was poisoned by thieves purport on excavation up the luck he'd
buried on his